Comparative molecular analyses of left-sided colon, right-sided colon, and rectal cancers
نویسندگان
چکیده
منابع مشابه
Comparative molecular analyses of left-sided colon, right-sided colon, and rectal cancers
Tumor sidedness has emerged as an important prognostic and predictive factor in the treatment of colorectal cancer. Recent studies demonstrate that patients with advanced right-sided colon cancers have a worse prognosis than those with left-sided colon or rectal cancers, and these patient subgroups respond differently to biological therapies. Historically, management of patients with metastatic...
متن کاملLaterality: Right-Sided and Left-Sided Colon Cancer
Colorectal cancer (CRC) can be characterized by the location of the primary tumor being within the colon [1]. Right-sided colon cancer (RCC) is derived from the embryologic midgut, including the proximal two-thirds of the transverse colon, ascending colon, and cecum. Left-sided colon cancer (LCC) is derived from the embryologic hindgut, which includes the distal third of the transverse colon, s...
متن کاملRight-sided colon cancer and left-sided colorectal cancers respond differently to cetuximab.
INTRODUCTION Right-sided colon cancer (RSCC) and left-sided colorectal cancer (LSCRC) differ with respect to their biology and genomic patterns. This study aimed to examine whether the primary tumor location is associated with the response to cetuximab in patients with metastatic colorectal cancer (mCRC). METHODS Patients with mCRC treated with cetuximab and standard chemotherapy as first- or...
متن کاملComparison of oncological outcomes of right-sided colon cancer versus left-sided colon cancer after curative resection
PROPOSE There are embryological origins, anatomical, histological, genetic, and immunological differences between right-sided colon cancer (RCC) and left-sided colon cancer (LCC). Many studies have sought to determine the survival and prognosis according to tumor location. This study aimed to analyze outcomes between RCC and LCC. MATERIAL AND METHOD Between January 2000 and December 2012, dat...
متن کاملA nationwide Danish cohort study challenging the categorisation into right-sided and left-sided colon cancer
OBJECTIVES The categorisation of colon cancer (CC) into right-sided (RCC) and left-sided (LCC) disease may not capture more subtle variances in aetiology and prognosis. In a nationwide study, we investigated differences in clinical characteristics and survival of RCC versus LCC and of the complete range of CC subsites. DESIGN Prospective nationwide cohort study. SETTING The database of the ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.21169